Sequence conservation analysis and in silico human leukocyte antigen-peptide binding predictions for the Mtb72F and M72 tuberculosis candidate vaccine antigens

Table 3 Prediction of HLA II-binding peptides for DRB3/4/5, DP and DQ alleles

HLA molecule	Mtb32A	Mtb39A	Mtb72F	M72
DRB3*01:01	18	7	31	31
DRB3*02:02	19	56	71	71
DRB3*03:01	51	82	125	125
DRB4*01:01	27	38	58	58
DRB5*01:01	32	85	109	109
DRB5*01:02	45	107	145	145
DQA105:01-DQB102:01^a	14	35	51	51
DQA102:01-DQB102:01^b	0	0	0	0
DQA105:01-DQB103:01^a	291	325	614	610
DQA103:01-DQB103:02^a	17	75	88	88
DQA104:01-DQB104:02^a	15	75	87	88
DQA101:01-DQB105:01^a	8	0	1	1
DQA101:02-DQB105:02	26	37	61	61
DQA101:02-DQB106:02^a	161	262	392	392
DPA102:01-DPB101:01^c	27	33	56	56
DPA101:03-DPB102:01^c	20	23	39	39
DPA101:03-DPB104:01^c	14	11	16	16
DPA101:03-DPB104:02^c	18	17	28	28
DPA102:02-DPB105:01^{b, c}	8	0	0	0
DPA102:01-DPB114:01	50	128	170	170

Prediction results represent the sum of the weak and strong binders. ^a Allele is among the 6 HLA-DQ molecules that reportedly are present in >85 % of populations worldwide [32]. ^b For these alleles, no frequencies are reported in the populations assessed (Additional file 2). ^c Allele is among the 5 HLA-DP molecules that reportedly are present in >90 % of populations worldwide [33]

ISSN: 1471-2172