Hyporesponsiveness of natural killer cells and impaired inflammatory responses in critically ill patients

BMC Immunology

Table 1 Clinical characteristics in control and ICU patient groups

	Control group (n = 24)	ICU patient (n = 24)	p ₀	p ₁
Age (year)	64.5 ± 2.05	64.6 ± 3.06	0.991
Male/Female n, (%)	18 (75.0) / 6 (25.0)	18 (75.0) / 6 (25.0)	1.000
BMI (kg/m²)	22.3 ± 0.40	22.4 ± 0.77	0.977
Height (cm)	163.7 ± 1.82	166.7 ± 1.41	0.201
Weight (kg)	64.0 ± 2.06	62.5 ± 2.69	0.669
Glucose (mg/dL)^∮	97.0 ± 4.95	211.4 ± 38.1	<0.001
Triglyceride (mg/dL)^∮	135.5 ± 9.41	104.8 ± 8.85	0.018
Total-cholesterol (mg/dL)^∮	216.3 ± 10.9	111.6 ± 7.16	<0.001
LDL-cholesterol (mg/dL)^∮	129.2 ± 10.1	61.4 ± 5.81	<0.001
HDL-cholesterol (mg/dL)^∮	59.8 ± 3.63	29.2 ± 2.85	<0.001
GOT (IU/L)^∮	28.5 ± 2.34	35.8 ± 6.02	0.708	0.155
GPT (IU/L)^∮	24.1 ± 1.91	22.2 ± 4.03	0.097	0.581
γ-GTP (U/L)^∮	34.8 ± 8.53	51.4 ± 15.9	0.967	0.520
BUN (mg/dL)^∮	15.1 ± 0.58	19.1 ± 2.54	0.811	0.294
Creatinine (mg/dL)^∮	0.82 ± 0.03	0.83 ± 0.07	0.556	0.567
Albumin (mg/dL)^∮	4.94 ± 0.11	2.77 ± 0.11	<0.001	<0.001
Prealbumin (mg/dL)^∮	25.6 ± 0.97	10.7 ± 0.97	<0.001	0.010
Leukocyte count (×10³/μL)^∮	5.65 ± 0.25	10.8 ± 0.92	<0.001	0.012
hs-CRP (mg/L)^∮	1.01 ± 0.29	113.1 ± 15.1	<0.001	<0.001
IL-12 (pg/mL)	41.5 ± 7.78	2.49 ± 1.59	<0.001	0.012
IFN-γ (pg/mL)	14.8 ± 2.61	0.00 ± 0.00	<0.001	0.031
TNF-α (pg/mL)^∮	11.7 ± 2.27	6.49 ± 0.70	0.094	0.816
IL-6 (pg/mL)^∮	2.55 ± 0.28	56.4 ± 16.9	<0.001	<0.001
IL-1β (pg/mL^∮∮	0.56 ± 0.05	2.54 ± 0.15	0.001	0.091

Mean ± SE.^∮tested by logarithmic transformation. p ₀: derived from independent t-test. p ₁: adjusted for glucose, triglyceride, LDL-cholesterol, and HDL-cholesterol

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