Fig. 5From: Progranulin inhibits LPS-induced macrophage M1 polarization via NF-кB and MAPK pathwaysEffects of PGRN on LPS-induced activation of NF-κB and MAPK pathways. Cells were treated with rPGRN (10 ng/ml), LPS (100 ng/ml) and LPS + rPGRN for 60 min. a-m The protein level of IKKα/β (a-c), IкBα (d, e), p65 (f, g), JNK (h, i), p38 (j, k) and ERK (l, m) were determined with Western blot. N = 3, P < 0.05 (*), P < 0.01 (**), P < 0.001 (***) or p < 0.0001(****)Back to article page