Fig. 6
BoNT/A and BIBN4096 improve the outcome of S. aureus skin infections. a The mice were pretreated with BoNT/A or PBS 7 days before infection, and the skin was infected with 1 × 108 CFUs of S. aureus, and the indexes were subsequently detected. b CGRP release from dorsal skin tissue of vehicle group and BoNT/A group 8 h after infection (n = 4/group); unpaired t test. c Bacterial burden of skin tissue in 2 groups of mice after 3 days of infection (n = 5/group); unpaired t test. d, e Comparison of body weight and core body temperature after infection in 2 groups of mice (n = 5/group); unpaired t test. f Survival curves of skin breakdown in 2 groups of mice (n = 11/group); log-rank (Mantel‒Cox) test. g The skin of WT mice was infected with 1 × 108 CFUs of S. aureus, and the mice were treated with BIBN4096 or PBS at 2 h postinfection, and the indexes were subsequently detected. h CGRP release from dorsal skin tissue of vehicle group and BoNT/A group 8 h after infection (n = 4/group); unpaired t test. i Bacterial burden of skin tissue in 2 groups of mice after 3 days of infection (n = 5/group); unpaired t test. j, k Comparison of body weight and core body temperature after infection in 2 groups of mice (n = 5/group); unpaired t test. l Survival curves of skin breakdown in 2 groups of mice (n = 11/group); log-rank (Mantel‒Cox) test. Data were pooled from two or three independent experiments