Helminth-derived proteins as immune system regulators: a systematic review of their promise in alleviating colitis

Table 1 The demographic data of all the studies included in this systematic review

Parasite	Intervention	Animal model	Comparison	Reference
Brugia malayi	rBmCys	DSS-induced colitis mice	PBS	[22]
Wuchereria bancrofti	rWbL2	DSS-induced colitis	Aluminum sulfate.	[23]
Schistosome Spp.	P28GST	TNBS-induced colitis in rats and mice	Ethanol solution	[24]
Schistosoma japonicum	rSjcystatin	TNBS-induced colitis in mice	PBS	[13]
Schistosoma japonicum	rSj16	DSS-induced colitis mice	PBS	[25]
Schistosoma haematobium	P28GST	TNBS-induced colitis mice	Vehicle-treated	[26]
Ancylostoma caninum	(AIP)-1 and AIP-1_Q119	TNBS-induced colitis in mice	PBS	[27]
Necator americanus	Na-AIP-1	TNBS-induced colitis mice	PBS	[28]
Necator americanus	Nak1	TNBS-induced colitis mice	Vehicle-treated	[29]
Ancylostoma caninum	Acan1	TNBS-induced colitis mice	Vehicle-treated	[29]
Ascaris lumbricoides	rAl-CPI	DSS-induced colitis mice	PBS	[30]
Trichinella spiralis	rTsP53	TNBS-induced colitis mice	Untreated	[31]
Trichinella spiralis	NBL-SP	TNBS-induced colitis	PBS	[32]
Trichinella spiralis	TsKaSPI, TsAdSPI	TNBS-induced colitis	PBS	[33]
Trichinella spiralis	rTsPmy	DSS-induced colitis	PBS	[34]
Clonorchis sinensis	CsStefin-1	DSS-induced colitis	PBS	[35]

Abbreviations rBmCys (Brugia malayi recombinant cystatin), rWbL2 (Wuchereria bancrofti larval recombinant protein), P28GST (Schistosome 28-kDa glutathione S-transferase), rSjcystatin (Schistosoma japonicum recombinant cystatin), rSj16 (S. japonicum recombinant 16-kDa secreted protein), (AIP)-1(Ancylostoma caninum recombinant protein anti-inflammatory protein-1), AIP-1_Q119 (the mutant recombinant protein AIP-1), Na-AIP-1 (Necator americanus Netrin domain-containing proteins), Nak1 (N.americanus low-MW peptide found in the excretory/secretory proteins), Acan1 (A. caninum low-MW peptides (∼4 kDa each) found in the excretory/secretory proteins), rAl-CPI (Ascaris lumbricoides recombinant cystatin protease), rTsP53 (Trichinella spiralis recombinant 53-kDa protein), NBL-SP (T. spiralis newborn larvae recombinant serine protease), TsKaSPI (T. spiralis Kazal-type serine protease inhibitors recombinant protein ), TsAdSPI (T.spiralis adult serine protease inhibitors recombinant protein), rTsPmy (T. spiralis paramyosin recombinant protein), CsStefin-1 (Clonorchis sinensis Type I cystatin recombinant protein)

ISSN: 1471-2172