Table 3 The effect of helminth-drive protein intervention on cytokine changes in the IBD-mouse model compared to control group

Schistosome cercariae

P28GST

↓ IL-1β, ↓ TNF-α, ↓ IL-17A

↑IL-10, ↑IL-13

[24]

Schisotosoma japonicum

rSjcystatin

↑IL-4, ↓IFN-γ

↑TGFβ, ↑IL-10, ↑ IL-13

[13]

Schistosoma japonicum

rSj16

↓IL-6, ↓ IL-1β, ↓TNF-α, ↓ IL-17A, ↓IFN-γ,

↑TGFβ, ↑IL-10

[25]

Ancylostoma caninum

AIP-1 and AIP-1_Q119

↓TNF-α, ↓ IL-17A, ↓IFN-γ

↑IL-10, ↑TGFβ

[27]

Ascaris lumbricoides

rAl-CPI

↓IL-6, ↓ IL-1β, ↓TNF-α, ↓IFN-γ,

↑TGFβ, ↑IL-10

[30]

Trichinella spiralis

rTsP53

↓TNF-α, ↓ IL-6

↑IL10 ↑TGFβ

[31]

Trichinella spiralis

NBL-SP

↓IFN- γ, ↓ IL-17

ND

[32]

Trichinella spiralis

TsKaSPI, TsAdSPI

↓IFN-γ

↑IL-4

[33]

Trichinella spiralis

rTsPmy

↓TNF-α ,↓ IL-1β, ↓IL-17, ↓IL-6, ↓IFN-γ

↑IL-10, ↑TGFβ

[34]

Parasite

Parasite product

Serum (Th1)

Serum (Th2)

Reference

Brugia malayi

rBmCys

↓TNF-α, ↓IFN-γ

↑IL-10

[22]

Schistosoma mansoni

SmSWP

↓TNF- α, ↓ IL-6, ↓IL-17a, ↓IFN-γ

↑ IL-4, ↑ IL-10

[37]

Schistosoma haematobium

P28GST

↑TNF-α,↓ IL-1β, ↓IL-6

ND

[26]

Trichinella spiralis

rTsP53

↓TNF-α, ↓IFN-γ

↑IL-13, ↑IL-4

[31]

Trichinella spiralis

NBL-SP

↓IFN- γ,↓TNF, ↓IL-17

↑IL-4, ↑IL-10, ↑TGF-β

[32]

Parasite

Parasite product

MLN or spleen (Th1)

MLN or spleen (Th2)

Reference

Brugia malayi

rBmCys

↓IL-6, ↓TNF-α, ↓ IL-17A, ↓IFN-γ

↑IL-10

[22]

Wuchereria bancrofti

rWbL2

↓IL-6, ↓TNF-α, ↓ IL-17A, ↓IFN-γ

↑IL-10

[23]

Schistosome cercariae

P28GST

↓ IL-1β, ↓TNF-α, ↓ IL-17A, ↓IFN-γ

↑IL-10, ↑IL-13

[24]

Schisotosoma japonicum

rSjcystatin

↓IFN-γ, ↓IL-17A

↑TGF-β, ↑IL-10

[13]

Schistosoma mansoni

SmSWP

↓IFN-γ, ↓ IL-17

↑TGF-β, ↑IL-10

[38]

Ascaris lumbricoides

rAl-CPI

↓IFN-γ

↑TGF-β, ↑IL-10

[30]

Trichinella spiralis

TsKaSPI, TsAdSPI

↓IFN- γ

↑IL-4

[33]

Clonorchis sinensis

CsStefin-1

↓ TNF-α, ↓FN-γ

↑ IL-10, ↑TGF-β

[35]