Helminth-derived proteins as immune system regulators: a systematic review of their promise in alleviating colitis

Table 4 The effect of helminth-drive protein intervention on pathological changes in the IBD-mouse model compared to the control group

Parasite	Parasite product	Body weight	Colon length	Disease activity index (DAI)	Myeloperoxidase (MPO) activity	Microscopic score/histological/ inflammation score	Macroscopic score	Reference
Brugia malayi	rBmCys	↑	↑	↓	↓	↓	ND	[22]
Wuchereria bancrofti	rWbL2	↑	↑	↓	ND	ND	ND	[23]
Schistosome cercariae	P28GST	↓	↑	ND	↓	↓	ND	[24]
Schisotosoma japonicum	rSjcystatin	↑	↑	↓	↓	↓	↓	[13]
Schistosoma japonicum	rSj16	↑	↑	↓	↓	↓	↓	[25]
Schistosoma haematobium	P28GST	↑	ND	↓	↓	↓	↓	[26]
Ancylostoma caninum	AIP-1 and AIP-1_Q119	↑	↑	ND	ND	↓	↓	[27]
Necator americanus	Na-AIP-1	↑	↑	ND	ND	↓	↓	[28]
Necator americanus	Nak1	↑	↑	ND	ND	ND	ND	[29]
Ancylostoma caninum	Acan1	↑	↑	ND	ND	ND	ND	[29]
Ascaris lumbricoides	rAl-CPI	↑	↑	↓	↓	↓	ND	[30]
Trichinella spiralis	rTsP53	↑	ND	↓	ND	↓	↓	[31]
Trichinella spiralis	NBL-SP	ND	↑	↑	ND	↓	↓	[32]
Trichinella spiralis	TsKaSPI, TsAdSPI	↓	ND	↓	↓	↓	↓	[33]
Trichinella spiralis	rTsPmy	↑	↑	ND	ND	↓	↓	[34]
Clonorchis sinensis	CsStefin-1	↑	↑	↓	ND	↓	↓	[35]

ISSN: 1471-2172